Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8749133 | Microbes and Infection | 2017 | 5 Pages |
Abstract
Binding exclusively to human-type receptors is a prerequisite for avian influenza viruses to transmit from human to human. We previously reported that 34% of H6 avian influenza viruses recognize the human-type receptor, but their affinity for the avian-type receptor remains higher than that for the human-type receptor. Here, we found that a single amino acid change from glutamine to leucine at position 226 of hemagglutinin caused a switch in receptor-binding preference from avian-type to human-type receptors and rendered A/chicken/Guangdong/S1312/2010(H6N2) capable of respiratory droplet transmission in guinea pigs.
Keywords
Related Topics
Life Sciences
Immunology and Microbiology
Immunology
Authors
Zhiyuan Qu, Shujie Ma, Huihui Kong, Guohua Deng, Jianzhong Shi, Liling Liu, Yasuo Suzuki, Hualan Chen,