Taenia crassiceps antigens induce a Th2 immune response and attenuate injuries experimentally induced by neurotoxoplasmosis in BALB/c mice

Experimental design - oral inoculation of Toxoplasma gondii cysts at day 0; serological confirmation of T. gondii infection at day 30 by indirect immunofluorescence (IFI); Intracranial inoculation of Taenia crassiceps antigens in a group of animals infected with T. gondii (CO-IN group) and in another group of animals without T. gondii infection (TCA group). Two control groups of non-infected animals were performed, one euthanized at 60 days and the other at 90 days. Histopathological and interleukin analyzes were performed. The co-inoculated group showed less severe brain injuries and lower levels of IFN-gamma when compared to the neurotoxoplasmosis group.54