Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8751457 | Virology | 2018 | 10 Pages |
Abstract
The management of hand-foot-and-mouth disease(HFMD) epidemic is difficult due to the frequent emergence of non-EV71 and non-CVA16 enteroviruses and some cases testing negative for HFMD-associated causative agents. To clarify the virus spectrum of mild and severe HFMD, a comprehensive virome analysis of 238 samples was performed using next-generation sequencing (NGS). The data revealed total thirteen mammalian- and plant- virus families and diverse viral populations including enteroviruses, common respiratory viruses, diarrhea-related viruses, plant viruses and anelloviruses. A total of 18 viruses from 7 virus families were identified in severe cases, versus 37 viruses from 12 virus families in mild cases. Moreover, complicated mixed-infections of enteroviruses with common respiratory viruses were mainly found in severe cases(Pâ¯=â¯0.013), while diarrhea-related viruses were mainly found in mild cases(Pâ¯<â¯0.001). This study provides the preliminary understanding of viromes both in mild and severe cases, which may benefit the detection of etiologic agents and prevention of HFMD.
Related Topics
Life Sciences
Immunology and Microbiology
Virology
Authors
Chunhua Wang, Shuaifeng Zhou, Wanhua Xue, Liang Shen, Wei Huang, Yi Zhang, Xuguang Li, Junzhi Wang, Hong Zhang, Xuejun Ma,