Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8751495 | Virology | 2018 | 6 Pages |
Abstract
The members of the Order Nidovirales share a similar genome organization with two overlapping nonstructural polyproteins encoded in the 5â² two-thirds and the structural proteins encoded in the 3â² third. They also express their 3â² region proteins from a nested set of 3â² co-terminal subgenomic messenger RNAs (sg mRNAs). Some but not all of the Nidovirus sg mRNAs also have a common 5â² leader sequence that is acquired by a discontinuous RNA synthesis mechanism regulated by multiple 3â² body transcription regulating sequences (TRSs) and the 5â² leader TRS. Initial studies detected a single major body TRS for each 3â² sg mRNA with a few alternative functional TRSs reported. The recent application of advanced techniques, such as next generation sequencing and ribosomal profiling, in studies of arteriviruses and coronaviruses has revealed an expanded sg mRNA transcriptome and coding capacity.
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Authors
Han Di, Ayisha A. McIntyre, Margo A. Brinton,