Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8751557 | Virology | 2018 | 11 Pages |
Abstract
Noroviruses are a leading cause of gastroenteritis in humans and it was recently revealed that noroviruses can infect B cells. We demonstrate that murine norovirus (MNV) infection can significantly impair B cell development in the bone marrow in a signal transducer and activator of transcription 1 (STAT1) dependent, but interferon signaling independent manner. We also show that MNV replication is more pronounced in the absence of STAT1 in ex vivo cultured B cells. Interestingly, using bone marrow transplantation studies, we found that impaired B cell development requires Stat1-/- hematopoietic cells and Stat1-/- stromal cells, and that the presence of wild-type hematopoietic or stromal cells was sufficient to restore normal development of Stat1-/- B cells. These results suggest that B cells normally restrain norovirus replication in a cell autonomous manner, and that wild-type STAT1 is required to protect B cell development during infection.
Related Topics
Life Sciences
Immunology and Microbiology
Virology
Authors
Charlie C. Hsu, Stacey M. Meeker, Sabine Escobar, Thea L. Brabb, Jisun Paik, Heon Park, Brian M. Iritani, Lillian Maggio-Price,