Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8751688 | Virus Research | 2018 | 12 Pages |
Abstract
We report a novel tri-genotypic recombinant Hepatitis B virus (HBV) strain circulating in Bangladesh. The strain is recombinant with the genotypes D, C and E, of which, genotype E was not reported before in Bangladesh. Additionally, the complete genome has a frameshift deletion of nine nucleotides from overlapping Surface and Polymerase genes, and a vaccine escape mutation, A128âV, in the surface protein. This is the first report with such unusual recombination event responsible for rapid liver cirrhosis in a 13âyear old patient in Bangladesh. This report may alert the clinicians to take the measure to prevent an upcoming outbreak of recombinant HBV.
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Authors
Modhusudon Shaha, Md. Hadisur Rahman, Munira Jahan, Shuvra Kanti Dey, Keshob Chandra Das, Abu Hashem, Md. Salimullah,