| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8751925 | Virus Research | 2018 | 19 Pages |
Abstract
Possible effects of K22 on nidovirus replication were studied in suitable cell lines. K22 concentrations significantly decreasing infectious titres of the viruses included in this study ranged from 25 to 50â¯Î¼M. Reduction of double-stranded RNA intermediates of viral replication in nidovirus-infected cells treated with K22 confirmed the anti-viral potential of K22. Collectively, the data show that K22 has antiviral activity against diverse lineages of nidoviruses, suggesting that the inhibitor targets a critical and conserved step during nidovirus replication.
Keywords
EAVSARS-CoVdsRNAMERS-CoVPEDVDMVNS5Anon-structural protein 5Adouble membrane vesiclesRTCPRRSVICTVFCoVIBVTCIDORFK22mRNANidovirusesFBSDMEMMiddle East respiratory syndrome coronavirusDMSODNAmessenger RNAdouble-stranded RNAdeoxyribonucleic acidribonucleic acidRNAAntiviral drugTissue culture infective doseDimethyl sulfoxidefoetal bovine serumSevere Acute Respiratory Syndrome Coronavirusendoplasmic reticulumopen reading frameDulbecco’s modified eagle’s mediumUTR یا untranslated regions untranslated regionHepatitis C virusHCVEquine arteritis virusPorcine epidemic diarrhea virusAvian infectious bronchitis virusPorcine reproductive and respiratory syndrome virusFeline coronavirus
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Authors
Julie Christiane Françoise Rappe, Adriaan de Wilde, Han Di, Christin Müller, Hanspeter Stalder, Philip V'kovski, Eric Snijder, Margo A. Brinton, John Ziebuhr, Nicolas Ruggli, Volker Thiel,