Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8752813 | American Journal of Obstetrics and Gynecology | 2018 | 12 Pages |
Abstract
The placenta ages as pregnancy advances, yet its continued function is required for a successful pregnancy outcome. Placental aging is a physiological phenomenon; however, there are some placentas that show signs of aging earlier than others. Premature placental senescence and aging are implicated in a number of adverse pregnancy outcomes, including fetal growth restriction, preeclampsia, spontaneous preterm birth, and intrauterine fetal death. Here we discuss cellular senescence, a state of terminal proliferation arrest, and how senescence is regulated. We also explore the role of physiological placental senescence and how aberrant placental senescence alters placental function, contributing to the pathophysiology of fetal growth restriction, preeclampsia, spontaneous preterm labor/birth, and unexplained fetal death.
Keywords
p16DNA damagesenescence-associated beta-galactosidaseTelomereOxidative stressSmall for gestational agePreterm laborPreterm birthAgingMembrane Rupturephosphoinositide 3-kinaseSenescence-associated secretory phenotypeFetal growth restrictionStillbirthfetal deathMammalian target of rapamycin complexTumor suppressor protein p53mitogen-activated protein kinasePreeclampsiaCellular senescencesenescence-associated heterochromatin focicyclin-dependent kinaseReactive oxygen species
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Authors
Zakia MPharm, Kaushik PhD, Lee NHIL, Roger PhD, MBBS,