Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8753136 | American Journal of Obstetrics and Gynecology | 2017 | 27 Pages |
Abstract
Transcriptomic analyses of living fetuses with myelomeningocele with the use of amniotic fluid supernatant cell-free RNA demonstrated differential regulation of specific genes and molecular pathways relevant to this central nervous system disorder, which resulted in a new understanding of pathophysiologic changes. The data also suggested the importance of pathways that involve secondary disease, such as inflammation, in myelomeningocele. These newly identified pathways may lead to hypotheses that can test novel therapeutic targets as adjuncts to fetal surgical repair.
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Authors
Tomo MD, Aimee MD, Alan MD, Lauren MD, John D. MD, Inbar MSc, Rebecca BS, Donna K. PhD, Diana W. MD,