| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8754043 | Asian Pacific Journal of Tropical Medicine | 2017 | 7 Pages |
Abstract
The present findings demonstrate that CDDP promotes abnormal activation of Nrf2 pathway and autophagy, leading to drug resistance of A549/CDDP cell. Curcumin attenuates this process and combat drug-resistance through its potent activation on Keap1 transcription, which is essential for interplay between oxidative stress induced Nrf2 activation and autophagy/apoptosis switch.
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Authors
Jie Shen, Ya-Juan Chen, Yuan-Wei Jia, Wen-Ying Zhao, Guang-Hai Chen, Ding-Feng Liu, Yun-Yu Chen, Chao Zhang, Xiao-Ping Liu,