Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8755113 | Auris Nasus Larynx | 2016 | 5 Pages |
Abstract
We describe the differences in U-LTE4 and other parameters in AIA compared to ATA, and correlation among parameters. We demonstrate that eosinophil-dominant inflammation starts in ethmoidal sinus clinicopathogenetically in CRS with asthma. U-LTE4 concentration was not exclusively associated with eosinophil counts in ethmoidal sinus. Eosinophils in ethmoidal sinus may be a major production site for CysLTs, particularly in AIA. CRS with AIA is assumed to be characterized by leukotriene-eosinophil cross-interaction in ethmoidal sinus.
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Authors
Tomoko Yamaguchi, Toyota Ishii, Kazuhiro Yamamoto, Noritaka Higashi, Masami Taniguchi, Makito Okamoto,