Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8755492 | Auris Nasus Larynx | 2013 | 4 Pages |
Abstract
Immunoglobulin G4-related disease (IgG4-RD) is an inflammatory condition associated with elevated serum IgG4 levels and tissue infiltration by IgG4-expressing plasma cells. Several inflammatory conditions associated with IgG4-RD have been reported. Warthin's tumor is a benign parotid gland tumor consisting of oncocytic epithelial cells and lymphoid stroma containing lymphoid follicles with reactive germinal centers. This is the first report describing a case of Warthin's tumor with possible involvement of IgG4-RD. The patient was a 71-year-old man presenting with swollen right parotid and bilateral submandibular glands. He had a history of a Warthin's tumor of the left parotid gland, autoimmune pancreatitis, and an inflammatory abdominal aortic aneurysm. Laboratory tests revealed a high serum IgG4 level. Histological examination of the resected parotid gland showed a Warthin's tumor and a nodule showing severe lymphocytic infiltration containing many IgG4-positive plasma cells. This case shows the possible involvement of Warthin's tumor with IgG4-RD.
Keywords
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Medicine and Dentistry (General)
Authors
Mitsuharu Aga, Satoru Kondo, Kazunori Yamada, Seiko Sawada-Kitamura, Sayaka Yagi-Nakanishi, Kazuhira Endo, Naohiro Wakisaka, Shigeyuki Murono, Mitsuhiro Kawano, Tomokazu Yoshizaki,