TNF-α upregulates VCAM-1 and NF-κB in fibroblasts from nasal polyps

The present study discovered that nasal fibroblasts produce VCAM-1 protein and mRNA and that production is increased by TNF-α stimulation. Furthermore, VCAM-1 expression in nasal fibroblasts is induced through an NF-κB-dependent pathway. These findings might provide a rationale for using NF-κB inhibitors as a treatment for nasal inflammatory diseases such as polyps.