Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8757616 | Contemporary Clinical Trials | 2018 | 9 Pages |
Abstract
Posttraumatic stress disorder (PTSD) commonly co-occurs with major depressive disorder (MDD) in both civilian and military/veteran populations. Existing, evidence-based PTSD treatments, such as cognitive processing therapy (CPT), often reduce symptoms of both PTSD and depression; however, findings related to the influence of comorbid MDD on PTSD treatment outcomes are mixed, and few studies use samples of individuals with both conditions. Behavioral activation (BA), an approach that relies on behavioral principles, is an effective treatment for depression. We have integrated BA into CPT (BA+CPT), a more cognitive approach, to address depressive symptoms among active duty service members with both PTSD and comorbid MDD. We describe an ongoing randomized controlled trial investigating the efficacy of our innovative, integrated BA+CPT intervention, compared with standard CPT, for active duty service members with PTSD and comorbid MDD. We detail the development of this integrated treatment, as well as the design and implementation of the randomized controlled trial, to evaluate its effect on symptoms.
Keywords
CPTMDDPTSD Checklist for DSM-5CAPS-5TBIPCL-5MLMDSM-5MADRSDODEBTPHQ-9Traumatic brain injuryPosttraumatic stress disorderPTSDMajor depressive disorderEvidence-based treatmentsCognitive processing therapyDiagnostic and Statistical Manual of Mental Disorders, 5th Editionbehavioral activationprolonged exposureMultilevel modelingMontgomery-asberg depression rating scaleMilitaryComorbidityDepartment of Veterans AffairsDepartment of Defense
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Authors
Kristen H. Walter, Lisa H. Glassman, W. Michael Hunt, Nicholas P. Otis, Cynthia J. Thomsen,