Article ID Journal Published Year Pages File Type
876387 Medical Engineering & Physics 2010 7 Pages PDF
Abstract

In order to improve the interfacial connection of hydroxyapatite (HAP) to poly-l-lactic acid (PLLA), γ-methacryloxypropyl-trimethoxysilane (γ-MPS) was used as a coupling agent to modify the surface of nano-HAP (NHAP) particles. The FTIR and XPS results showed γ-MPS was successfully bonded on the surface of NHAP. Silane modified nano-HAP (MNHAP) and PLLA were fabricated to nano-composite scaffold by a thermally induced phase separation method. The characterization of the composite scaffold showed that the scaffold had a nano-fibrous PLLA network (fiber size 100–800 nm), an interconnective microporous structure (1–8 μm) and high porosity (>90%). MNHAP was homogeneously distributed in the scaffold, also partly set in the nano-PLLA fibers. As a result, the compressive modulus and the protein adsorption of PLLA/MNHAP (80:20, w/w) composite scaffold increased to 4.2-fold and 2.8-fold compared with those of a pure PLLA scaffold. Incorporating MNHAP into PLLA network also buffered the pH reduction and reduced the weight loss in vitro degradation significantly.

Related Topics
Physical Sciences and Engineering Engineering Biomedical Engineering
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