Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8766027 | Porto Biomedical Journal | 2017 | 5 Pages |
Abstract
As clinical oncology evolves with new treatment options becoming available, there is an increasing demand on anatomic imaging for the assessment of patients at different stages. Imaging with hyperpolarized 13C-labelled cell substrates has the potential to become a powerful tool in many steps of clinical evaluation, offering a new metabolic metric and therefore a more personalised approach to treatment response. This articles explores the metabolic basis and potential for translation of hyperpolarised pyruvate as a dynamic nuclear polarisation probe in clinical oncology.
Keywords
MRSIDNPMRS18F-FDGPPPHyperpolarizedDCE18FluorodeoxyglucosePCAAdenosine TriphosphateATPImagingMagnetic resonance spectroscopic imagingMolecular imagingcomputed tomographyPositron emission tomographyCancerPancreatic cancermagnetic resonance spectroscopyDynamic nuclear polarisationMetabolismpentose phosphate pathwayPETPyruvatedynamic contrast enhanced
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Authors
Eva M. Serrao, Kevin M. Brindle,