Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8768927 | Translational Research | 2018 | 14 Pages |
Abstract
Nuclear factor-κB (NF-κB) has been widely implicated in the development and progression of cancer. In colorectal cancer (CRC), NF-κB has a key role in cancer-related processes such as cell proliferation, apoptosis, angiogenesis, and metastasis. The role of NF-κB in CRC is complex, owed to the cross talk with other signaling pathways. Although there is sufficient evidence gained from cell lines and animal models that NF-κB is involved in cancer-related processes, because of a lack of studies in human tissue, the clinical evidence of its importance is limited in patients with CRC. This review summarizes evidence relating to how NF-κB is involved in the development and progression of CRC and comments on future work to be carried out.
Keywords
VEGFRHDACHUVECMCP-1APCSTAT 3IKKNLSHIFIL-8EGFRNIKNIBPIKKαIKKβreceptor activator of nuclear factor kappa-BAMPK/mTORTNFGROαRANKLIL-6NF-κBMMP5-FUCOX-2IL-1TGFβTNFαIκB kinaseIL1βadenomatous polyposis coliOlfactomedininterleukin 1interleukin 1 betainterleukin 6Interleukin 8BAFFTransforming Growth Factor Betatumour necrosis factor alphaEMTdimerization domainColorectal cancerHuman umbilical vein endothelial cellsIntestinal epithelial cellscyclooxygenase 2B-cell activating factortumour necrosis factorHypoxia Inducible Factornuclear factor-kappaB5-fluorouracilTRAILTNF-related apoptosis-inducing ligandmatrix metalloproteinasehistone deacetylasemonocyte chemoattractant protein 1CRCIECEpithelial-mesenchymal transitionvascular endothelial growth factor receptorEpidermal growth factor receptor
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Authors
Meera Patel, Paul G. Horgan, Donald C. McMillan, Joanne Edwards,