Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8768956 | Translational Research | 2018 | 12 Pages |
Abstract
Thyroid nodules assessed with ultrasound and fine-needle aspiration biopsy are diagnosed as “suspicious” or “indeterminate” in 15%-20% of the cases. Typically, total thyroidectomy is performed in such cases; however, only 25%-50% are found to be cancerous upon final histopathologic analysis. Here we demonstrate optical coherence tomography (OCT) imaging of the human thyroid as a potential intraoperative imaging tool for providing tissue assessment in real time during surgical procedures. Fresh excised tissue specimens from 28 patients undergoing thyroid surgery were imaged in the laboratory using a benchtop OCT system. Three-dimensional OCT images showed different microstructural features in normal, benign, and malignant thyroid tissues. A similar portable OCT system was then designed and constructed for use in the operating room, and intraoperative imaging of excised thyroid tissue from 6 patients was performed during the surgical procedure. The results demonstrate the potential of OCT to provide real-time imaging guidance during thyroid surgeries.
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Authors
Sarah J. Erickson-Bhatt, Kelly J. Mesa, Marina Marjanovic, Eric J. Chaney, Adeel Ahmad, Pin-Chieh Huang, Z. George Liu, Kelly Cunningham, Stephen A. Boppart,