Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8769060 | Translational Research | 2017 | 40 Pages |
Abstract
Lipidomics is a rapidly developing field of study that focuses on the identification and quantitation of various lipid species in the lipidome. Lipidomics has now emerged in the forefront of scientific research due to the importance of lipids in metabolism, cancer, and disease. Using both targeted and untargeted mass spectrometry as a tool for analysis, progress in the field has rapidly progressed in the last decade. Having the ability to assess these small molecules in vivo has led to better understanding of several lipid-driven mechanisms and the identification of lipid-based biomarkers in neurodegenerative disease, cancer, sepsis, wound healing, and pre-eclampsia. Biomarker identification and mechanistic understanding of specific lipid pathways linked to a disease's pathologies can form the foundation in the development of novel therapeutics in hopes of curing human disease.
Keywords
EPAHTSESIFT-ICR MSPLS-DAHDLACSAβCOX-2COX-112-HETEMRMPGE2UPLCRNSqTOFLPCPrPS1PHMG-CoAP450LPAaSAHLTB4PLA2ACOGTxA2PIHcPLA2αPGE1SPMSTXB2PD1Resolvin E115-HETECEHLC/MS-MSLXA4PIP2phthiocerol dimycocerosateQqQPDIMTXMPGJ2Prostaglandin J2Prostaglandin F2 alpha5-HETECardiolipinsRvE1hydroxymethylglutaryl-CoA synthaseRvD1C1PRvE2RvD2Resolvin D2HMGCSPgf2aCERKHydroxymethylglutaryl-CoA11-dehydro-TXB2high-density lipoproteinm/zResolvin D1ROSAcylcarnitinesamyloid-betaphospholipase A2sphingomyelinSphingomyelinasesSphingosine-1-phosphateArachidonic acidEicosapentaenoic aciddocosahexaenoic acidphosphatidic acidlysophosphatidic acidPolyunsaturated fatty acidPUFALOXICUintensive care unitAlzheimer’s diseasePartial least squares discriminant analysisthromboxane B2Thromboxane A2ELISAEnzyme-linked immunosorbent assayAneurysmal subarachnoid hemorrhageDHAquadrupole time-of-flightCeramide kinaseCeramide-1-phosphateCytochrome P450cyclooxygenase 1cyclooxygenase 2endoplasmic reticulumTriple quadrupole mass spectrometryFourier transform ion cyclotron resonance mass spectrometryLiquid chromatography mass spectrometryhigh-throughput screeningphosphatidylinositolphosphatidylcholinePhosphatidylglycerolsphosphatidylethanolaminePhosphatidylserinephosphatidylinositol 4,5-bisphosphatepregnancy-induced hypertensionLeukotriene B4LysophosphatidylcholinelipoxygenaseLow-density lipoproteinLDLlipoxin A4Cerebrospinal fluidCSFmass/charge ratiomultiple reaction monitoringPAMAMProstaglandin E1Prostaglandin E2platelet-rich plasmaPolyamidoamineTCA cycleHigh pressure liquid chromatographyUltra-high pressure liquid chromatographyHPLCcholesterol ester hydrolasereactive nitrogen speciesReactive oxygen specieselectrospray ionization
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Authors
Daniel J. Stephenson, L. Alexis Hoeferlin, Charles E. Chalfant,