| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8771940 | The Journal of Urology | 2017 | 27 Pages |
Abstract
In patients undergoing radical nephroureterectomy for upper tract urothelial carcinoma loss of PTEN protein expression is rare but associated with features of biologically aggressive disease such as higher grade and stage as well as lymph node metastasis. Loss of PTEN expression was associated with overall mortality. PTEN loss seemed to promote worse outcomes in this relatively small group of patients.
Keywords
UCBPI3KUTUCPTEN phosphohydrolaseRNUTMAmTORUrothelial carcinoma of bladderLVIUreterIHCImmunohistochemistryLymphovascular invasionNeoplasm recurrencephosphatase and tensin homologPhosphatidylinositol 3-kinaseLocalTissue microarrayRadical nephroureterectomymammalian target of rapamycinPtenUpper tract urothelial carcinomaCarcinomaKidney
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Authors
Malte Rieken, Shahrokh F. Shariat, Jose A. Karam, Beat Foerster, Francesca Khani, Kilian Gust, Mohammad Abufaraj, Christopher G. Wood, Alon Z. Weizer, Jay D. Raman, Charles C. Guo, Nathalie Rioux-Leclercq, Andrea Haitel, Karim Bensalah, Yair Lotan,