Biopsy Detected Gleason Pattern 5 is Associated with Recurrence, Metastasis and Mortality in a Cohort of Men with High Risk Prostate Cancer

Article ID	Journal	Published Year	Pages	File Type
8771948	The Journal of Urology	2017	23 Pages	PDF

Abstract

Preoperative subclassification of high risk prostate cancer by biopsy Gleason grade (4 + 4 vs any Gleason pattern 5) identified men at highest risk for progression. Any Gleason 5 on biopsy is associated with a greater risk of metastasis, and prostate cancer specific and overall mortality. Grouping all Gleason 8-10 tumors together as high risk lesions may fail to fully stratify men at highest risk for poor outcomes.

Keywords

BCR PSA Prostate specific antigen Shared Equal Access Regional Cancer Hospital SEARCH Neoplasm recurrence Biochemical recurrence Local Mortality Prostatic neoplasms Prostatectomy

Related Topics

Health Sciences Medicine and Dentistry Nephrology

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Biopsy Detected Gleason Pattern 5 is Associated with Recurrence, Metastasis and Mortality in a Cohort of Men with High Risk Prostate Cancer

Authors

Sean P. Stroup, Daniel M. Moreira, Zinan Chen, Lauren Howard, Jonathan H. Berger, Martha K. Terris, William J. Aronson, Matthew R. Cooperberg, Christopher L. Amling, Christopher J. Kane, Stephen J. Freedland,