| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8773738 | Kidney International Reports | 2018 | 7 Pages |
Abstract
Our study shows that long-term therapy with topiramate in children is associated with persistent hypercalciuria and metabolic acidosis, which can lead to nephrocalcinosis and/or nephrolithiasis. All children initiating topiramate therapy should have baseline and follow-up urinary calcium/creatinine studies, serum electrolytes, and periodic renal ultrasonography, if the urinary calcium/creatinine ratio increases to a level above normal for age.
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Authors
Sarah M. Barnett, Anthony H. Jackson, Beth A. Rosen, Jane L. Garb, Gregory L. Braden,