Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8776616 | Best Practice & Research Clinical Obstetrics & Gynaecology | 2017 | 28 Pages |
Abstract
Approximately 15% of couples are infertile. Male factors contribute to infertility in over 50% of cases. Identifiable genetic abnormalities contribute to 15%-20% of the most severe forms of male infertility, azoospermia. In this chapter, we explore known genetic causes of male infertility such as Klinefelter syndrome, XYY men, Kallmann syndrome, y-microdeletions, Robertsonian translocations, autosomal inversions, mixed gonadal dysgenesis, x-linked and autosomal gene mutations, and cystic fibrosis transmembrane conductance regulator abnormalities. We also briefly comment on novel biomarkers for male infertility.
Keywords
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Authors
Ryan MD, Peter N. MD,