Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8776619 | Best Practice & Research Clinical Obstetrics & Gynaecology | 2017 | 23 Pages |
Abstract
Preimplantation genetic diagnosis (PGD) was first reported in 1990. Thereafter, more and more indications for PGD, including monogenic diseases (MGD) and translocations, are presently available, and the list of indications of PGD is expanding from early-onset and serious conditions to late-onset diseases. Polymerase chain reaction has been used for PGD of MGD, while newer techniques, including karyomapping and next-generation sequencing, emerge in recent decade. The limitations of various methods for PGD are discussed in this review.
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Authors
Vivian Chi Yan (Dr), Judy F.C. (Ms), William Shu Biu PhD, Prof, Pak Chung MD, Prof,