Article ID Journal Published Year Pages File Type
8778213 European Journal of Obstetrics & Gynecology and Reproductive Biology 2018 7 Pages PDF
Abstract
This study demonstrates increased placental expression of HIF-1α and CHOP in preeclampsia compared to normotensive pregnancies which correlate to their increased syncytiotrophoblast microvesicles concentration in maternal circulation. These findings indicate that placental hypoxia and ER stress are interrelated contributory factors to the pathogenesis of PE and the consequential release of placental derived debris into the maternal circulation.
Related Topics
Health Sciences Medicine and Dentistry Obstetrics, Gynecology and Women's Health
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