Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8778213 | European Journal of Obstetrics & Gynecology and Reproductive Biology | 2018 | 7 Pages |
Abstract
This study demonstrates increased placental expression of HIF-1α and CHOP in preeclampsia compared to normotensive pregnancies which correlate to their increased syncytiotrophoblast microvesicles concentration in maternal circulation. These findings indicate that placental hypoxia and ER stress are interrelated contributory factors to the pathogenesis of PE and the consequential release of placental derived debris into the maternal circulation.
Keywords
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Authors
S. Verma, P. Pillay, T. Naicker, J. Moodley, I. Mackraj,