Efficacy and Tolerability of Mirabegron Compared with Antimuscarinic Monotherapy or Combination Therapies for Overactive Bladder: A Systematic Review and Network Meta-analysis

This study assessed the efficacy and tolerability of different drug treatments for OAB. Mirabegron 50 mg was as effective as antimuscarinic therapy, with fewer common, bothersome side effects such as dry mouth, constipation, and urinary retention. Combination treatment of solifenacin 5 mg plus mirabegron 25 or 50 mg was more effective than mirabegron 50 mg alone, but with more anticholinergic side effects.