| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8778383 | European Urology | 2018 | 4 Pages |
Abstract
In the largest study of its kind, we sequenced â¼20 000 genes in 919 men with testicular germ cell tumour (TGCT) and 1609 TGCT-free individuals and found no evidence of a single major gene underlying predisposition to TGCT (in the manner of BRCA1 for breast cancer). Instead, familial risk of TGCT is likely to be due to varying dosages of hundreds of minor genetic factors.
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Authors
Kevin Litchfield, Chey Loveday, Max Levy, Darshna Dudakia, Elizabeth Rapley, Jeremie Nsengimana, D. Tim Bishop, Alison Reid, Robert Huddart, Peter Broderick, Richard S. Houlston, Clare Turnbull,