Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8778426 | European Urology | 2018 | 10 Pages |
Abstract
Prostatectomy specimens (13 261) were analyzed to estimate the relevance of small Gleason 5 elements in prostate cancers. Even the smallest Gleason 5 areas markedly increased the risk of prostate-specific antigen recurrence after surgery. Larger fractions of Gleason 5 patterns had less further impact on prognosis. Based on this, a numerical Gleason score (integrated quantitative Gleason score) was defined by the percentages of Gleason 4 and 5 patterns, enabling a refined estimate of patient prognosis.
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Authors
Guido Sauter, Till Clauditz, Stefan Steurer, Corinna Wittmer, Franziska Büscheck, Till Krech, Florian Lutz, Maximilian Lennartz, Luisa Harms, Lisa Lawrenz, Christina Möller-Koop, Ronald Simon, Frank Jacobsen, Waldemar Wilczak, Sarah Minner,