Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8782858 | Journal of Reproductive Immunology | 2018 | 8 Pages |
Abstract
In conditioned media of PIBF-deficient JEG-3 cells, LC cells and OC cells MMP-9 activity was reduced to 36% 35%, and 65% respectively compared to controls. Though PIBF knock down did not affect migration, in JEG-3 cells, LC primary cells and OC primary cells PIBF deficiency resulted 20%, 50% and 50% decrease of invasion respectively. PIBF silencing resulted in increased E-cadherin expression, suggesting that by down regulating E-cadherin expression, PIBF might interfere with the cell-cell adhesion mechanisms and by increasing MMP activity induced extracellular matrix degradation, facilitates the invasion of tumour cells.
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Authors
TÃmea Balassa, Gergely Berta, László Jakab, Noémi Bohonyi, Júlia Szekeres-Bartho,