Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8783281 | Middle East Fertility Society Journal | 2017 | 4 Pages |
Abstract
Objective: Lead is a multi-organ toxicant implicated in various diseases including testicular toxicity. In search of cheap and readily available antidote this study has investigated a beneficial role of activated charcoal in lead induced testicular toxicity in male albino rats. Materials and Method: Eighteen male albino rats were divided into three groups of six rats per group. Group 1 (control rats) received deionised water (10Â ml/kg), group 2 was given lead acetate solution 60Â mg/kg and group 3 rats were given lead acetate (60Â mg/kg) followed by Activated charcoal, AC (1000Â mg/kg) by oral gavage daily for 28Â days. Absolute and relative weights of testis, epididymal sperm reserve, testicular sperm count, percent sperm motility and percent sperm viability were monitored. Results: AC failed to show any significant beneficial effect in ameliorating lead induced testicular toxicity. Conclusions: There seem to be a poor adsorption on lead onto AC in vivo.
Keywords
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Authors
Samuel James Offor, Herbert Orji Chinedu Mbagwu, Orish Ebere Orisakwe,