Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8787422 | Journal of Cancer Research and Practice | 2017 | 4 Pages |
Abstract
Mismatch repair deficiency (dMMR) or microsatellite instability (MSI) has been reported as a predictive biomarker for responses to programmed death-1 (PD-1) blockade in metastatic colorectal cancer. A high response rate to anti-PD-1 therapy was observed in other cancer types with MSI. We report a chemotherapy-refractory metastatic gastric cancer patient with dMMR and MSI who responded remarkably well to pembrolizumab, a PD-1 monoclonal antibody. The satisfactory objective response has lasted for more than 24 months as of this report.
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Authors
Ting-Hui Wu, Emily Han-Chung Hsiue, Chang-Tsu Yuan, Li-Hui Tseng, Chia-Chi Lin, Kun-Huei Yeh,