Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8787748 | Journal of Thoracic Oncology | 2018 | 35 Pages |
Abstract
Our results suggest a benefit to joint targeting of the estrogen and inflammatory pathways for NSCLC prevention. Combining AIs with nonsteroidal anti-inflammatory drugs reduces circulating E2, proinflammatory cytokines, and macrophage recruitment in the lung microenvironment after tobacco exposure. This strategy could be particularly effective in women who have underlying pulmonary inflammatory diseases.
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Authors
Laura P. PhD, Mariya PhD, Beatriz BS, Shira MS, Brenda F. PhD, Brenda PhD, Jill M. PhD,