Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8789980 | Urologic Oncology: Seminars and Original Investigations | 2018 | 7 Pages |
Abstract
Sarcomatoid transformation in renal cell carcinoma, so called sacromatoid RCC (sRCC), is associated with an aggressive behavior and a poor prognosis. Current therapeutic approaches are largely ineffective. Recent studies looking into the genomic and molecular characterization of sRCCs have provided insights into the biology and pathogenesis of this entity. These advances in molecular signatures may help development of effective treatment strategies. We herein present a review of recent developments in the pathology, biology, and treatment modalities in sRCC.
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Authors
Nemer El M.D., Steven C. M.D., Ph.D., Asit K. M.D., Ph.D.,