| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 8795031 | Progress in Retinal and Eye Research | 2018 | 15 Pages |
Abstract
Our review provides an overview of genetic and non-genetic factors characterizing AMD susceptibility in Italian population, outlining the differences with respect to the worldwide populations. Altogether, these data reflect historical, geographic, demographic and lifestyle peculiarities of Italian population. The role of epigenetics, pharmacogenetics, comorbities and genetic counseling in the management of AMD patients have been described, in the perspective of the application of a “population-specific precision medicine” approach addressed to prevent AMD onset and improve patients' quality of life.
Keywords
ECMCrXCNVRNFLRPEiOpmiRNAsAMDBRMPDTROSgeographic atrophyAlzheimer diseaseCardiovascular diseasesParkinson diseaseGene interactionsPopulationsVisual acuitySusceptibilityPhotodynamic therapyMacular degenerationCVDage-related macular degenerationTranscription factorsBruch's membraneRetinal nerve fiber layerextra-cellular matrixMicro-RNAsC-reactive proteinCRPGeneticsReactive oxigen species
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Authors
Raffaella Cascella, Claudia Strafella, Valerio Caputo, Valeria Errichiello, Stefania Zampatti, Filippo Milano, Saverio Potenza, Silvestro Mauriello, Giuseppe Novelli, Federico Ricci, Andrea Cusumano, Emiliano Giardina,