Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8795236 | Survey of Ophthalmology | 2017 | 22 Pages |
Abstract
A 19-year-old man noticed blurred vision in his right eye. He had an intraocular pressure of 60 versus 12Â mmHg in the fellow eye. He was initially diagnosed with an atypical, advanced pigmentary glaucoma. The intraocular pressure did not respond to maximal medication, deep sclerectomy, goniopuncture, and 2 cyclophotocoagulations. Sixteen months after presentation, malignancy was first suspected, and the eye was enucleated. A ring melanoma of the anterior chamber angle was confirmed by the histopathologic examination. Normal nuclear staining for breast cancer 1 gene (BRCA1)-associated protein 1 suggested that the tumor was likely of disomy 3 type with a favorable prognosis. No local or systemic recurrence has developed within 4Â years. A literature review of this rare type of minimal volume diffuse uveal melanoma identified 18 additional patients. The initial diagnosis in 18 of the 19 patients with a ring melanoma of the anterior chamber angle was unilateral glaucoma with a median intraocular pressure of 40Â mmHg and an age range of 16-76Â years. Liver metastasis developed in 5 of 12 patients older than 45Â years. This rare subtype is estimated to account for 0.05%-0.16% of all uveal melanomas.
Keywords
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Authors
Anni MD, Päivi MD, FEBO, Eija MD, FEBO, Ari MD, Joni A. MD, FEBO, Tero T. MD, FEBO,