Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8800738 | Journal of Shoulder and Elbow Surgery | 2018 | 13 Pages |
Abstract
PDGFRβ+ PDGFRα+ cells directly contribute to fibrosis and fatty degeneration after massive rotator cuff tears in the mouse model. In addition, CWHM-12 treatment inhibits fibrogenesis from PDGFRβ+ PDGFRα+ cells in vitro. Clinically, perioperative PDGFRβ+ PDGFRα+ cell inhibition may limit rotator cuff tissue degeneration and, ultimately, improve surgical outcomes for massive rotator cuff tears.
Keywords
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Authors
Andrew R. MD, MBE, Benjamin V. MD, Gina M. MD, Allison BS, Claire D. MD, Brandon BS, Paras BS, Sai K. BS, Iain R. MBChB, PhD, Bruno PhD, Ayelet PhD, Frank A. MD,