Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8804586 | The Spine Journal | 2018 | 26 Pages |
Abstract
BB-1 significantly enhanced the bone formation induced by a PLGA fiber-reinforced CPC in sheep lumbar osteopenia. A single local dose as low as 100âµg BB-1 was sufficient to augment middle- to long-term bone formation. A CPC containing the novel GDF5 mutant BB-1 may thus represent an alternative to the bioinert, supraphysiologically stiff polymethylmethacrylate cement presently used to treat osteoporotic vertebral fractures by vertebroplasty and kyphoplasty.
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Authors
Francesca Gunnella, Elke PhD, Stefan PhD, Victoria Horbert, Long MD, Joerg MD, Juliane Borowski, Sabine MD, Harald MD, Andre MD, Bernhard PhD, Jens PhD, Jörg PhD, Klaus D. PhD, Frank PhD, Raimund W. MD, Olaf MD, Matthias MD,