Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8804630 | The Spine Journal | 2018 | 26 Pages |
Abstract
This study demonstrated that BMP-2/7 heterodimer has stronger bone induction ability without accompanying increased inflammatory reactions (the increased BF-to-IM ratio) than those observed by BMP-2 or BMP-7 homodimers. These results suggest that BMP-2/7 heterodimer can be an alternative to BMP-2 and BMP-7 homodimers in clinical applications, although further translational studies, including whether lower doses of BMP heterodimer may produce similar bone formation compared with the BMP homodimers but produce a reduced inflammatory response, are required.
Keywords
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Authors
Takashi MD, PhD, Tokimitsu MD, PhD, Yuki PhD, Sadaaki MD, Takahiro MD, Shota MD, Yusuke MD, Satoru MD, PhD, Yoshichika PhD, Hideki MD, PhD,