Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8807158 | Annals of Diagnostic Pathology | 2018 | 6 Pages |
Abstract
We analyzed a series of renal tumors combining the features of PRCC/OPRCC and RO, that included pseudostratification and mostly high grade oncocytic cells lining papillary/tubulopapillary structures, karyotype characterized by loss of 1p36, loss of chromosome Y, rearrangement of CCND1 gene and numerical changes of chromosome 14. Despite the chromosomal numerical abnormalities typical of RO, we classified these tumors as part of the spectrum of PRCC because of their predominant papillary/tubulopapillary architecture, immunoprofile that included reactivity for AMACR, vimentin and lack of reactivity for CD117, all of which is incompatible with the diagnosis of RO. This study expands the morphological spectrum of PRCC by adding a cohort of diagnostically challenging cases, which may be potentially aggressive.
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Authors
Kvetoslava Michalova, Petr Steiner, Reza Alaghehbandan, Kiril Trpkov, Petr Martinek, Petr Grossmann, Delia Perez Montiel, Maris Sperga, Lubomir Straka, Kristyna Prochazkova, Dana Cempirkova, Vladimir Horava, Stela Bulimbasic, Kristyna Pivovarcikova,