Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8807229 | Annals of Diagnostic Pathology | 2018 | 5 Pages |
Abstract
In our study, a statistically significant association between c-Myc expression and p27 loss and the triple negative breast cancers (TNBC) was found in AA women. A recent study found that constitutive c-Myc expression is associated with inactivation of the axin 1 tumor suppressor gene. p27 inhibits cyclin dependent kinase2/cyclin A/E complex formation. Axin 1 and CDK inhibitors may represent possible therapeutic targets for TNBC.
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Authors
Farhan Khan, Luisel J. Ricks-Santi, Rabia Zafar, Yasmine Kanaan, Tammey Naab,