Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8807317 | Diagnostic Histopathology | 2018 | 4 Pages |
Abstract
Combined neoplasms of the lung are defined by the WHO classification as an admixture of a small or large cell neuroendocrine carcinoma and a non-neuroendocrine component. However, rare cases of carcinoids combined with a non-neuroendocrine component have been described. These tumor types are not included as a specific entity in the WHO classification of pulmonary neoplasms and their pathogenesis is still unknown. We describe the clinico-pathologic and molecular features of a mixed (combined) lung neoplasm composed of adenocarcinoma and atypical carcinoid. The NGS analysis of the two different tumor components shows a similar molecular profile suggesting their monoclonal origin from a transformed stem/progenitor tumor cell which acquires a divergent differentiation during its development and progression. We also suggest the use of the recently proposed term of mixed neuroendocrine/non-neuroendocrine neoplasm (MiNEN) to define mixed (combined) neoplasms of the lung, because it seems to better cover the wide spectrum of different possible combinations of neuroendocrine and non-neuroendocrine components.
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Authors
Stefano La Rosa, Michele Simbolo, Francesca Franzi, Silvia Uccella, Andrea Imperatori, Elisa Nardecchia, Nicola Rotolo, Lorenzo Dominioni, Aldo Scarpa, Fausto Sessa,