Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8807486 | Human Pathology | 2018 | 14 Pages |
Abstract
Here, we present a case of non-small cell lung carcinoma (NSCLC) with widespread and strong nuclear immunopositivity for both thyroid transcription factor-1 (TTF-1) and ÎNp63/p40 (p40). Double immunofluorescence for TTF-1 and p40 showed coexpression of both markers in the tumor cells. Furthermore, PTEN (pHis123Asp) and TP53 (pVal272Leu) mutations were identified as possible mitogenic driver mutations by next-generation sequencing. To the best of our knowledge, this is the first case of NSCLC harboring concurrent PTEN and TP53 mutations with widespread and strong coexpression of TTF-1 and p40, which has been confirmed in the resected specimen, and only the second documented case of NSCLC with TTF-1 and p40 diffuse coexpression in the carcinoma cells from the same individual. Our case illustrates the possibility that poorly differentiated NSCLCs with widespread and strong nuclear positivity for TTF-1 and p40 may be an underrecognized and new entity.
Related Topics
Health Sciences
Medicine and Dentistry
Pathology and Medical Technology
Authors
Takuo MD, PhD, Kazuya MD, PhD, Yuka MD, Keiko MT,CT(IAC), Hisashi Tomita, Kaoru PhD, Yoshiyuki MD, PhD, Fumiyuki MD, PhD, Kenji MD, PhD, Tsuyoshi MD, PhD, Takashi MD, PhD,