Long-term urinary symptoms in adolescent and adult women with congenital adrenal hyperplasia

Patients with CAH appeared to have overall normal urinary flow but increased post-void residual volumes. The data suggested that this population of patients has an increased probability of incontinence, urgency, and frequency when compared to a control population. These results confirmed findings of other small studies; however, it remains unclear if these changes reflected the underlying diagnosis or were a consequence of management.Summary table. Frequency of urinary symptoms as reported by congenital adrenal hyperplasia patients compared to previously reported control population data.Symptom typeCongenital adrenal hyperplasia patientsControl populationP-valueIncontinence symptomsFrequency of incontinence episodes59% (10/17)15% (3/20)0.008*Stress incontinence41% (7/17)25% (5/20)0.48Urge incontinence59% (10/17)5% (1/20)0.001*Unexplained incontinence47% (8/17)5% (1/20)0.005*Nocturnal incontinence29% (5/17)0% (0/20)0.014*Voiding symptomsIntermittent stream38% (8/21)30% (6/20)0.59Hesitancy48% (10/21)25% (5/20)0.133Frequency (9+)24% (5/21)0% (0/20)0.020*Filling symptomsNocturia (2+)14% (3/21)5% (1/20)0.317Bladder pain24% (5/21)10% (2/20)0.240Straining14% (3/21)0% (0/20)0.079Urgency57% (12/21)20% (4/20)0.015**P < 0.05 regarded as significant.