Cryopreservation of testicular tissue in pre-pubertal and adolescent boys at risk for infertility: A low risk procedure

In this series, pre-pubertal TT biopsy for cryopreservation was safely performed, and was most often coordinated concomitantly with other medically necessary procedures. The safety profile reported herein supports performing this procedure while technological advances fulfill the requirements to make it a viable option for future fertility.Table. Patient characteristics.Age at surgery (years)DiagnosisPlatelet (×109/L)7.8Relapse high risk precursor B cell ALLa2706.4Burkitt's lymphoma52014.6Relapsed intravascular large B cell lymphomaa788.8Rhabdomyosarcoma of R parameningeal3523.4Aplastic anemia5112.6Relapsed precursor B ALLa1344.4Neuroblastomaa623.8Neuroblastoma47410.4Metastatic medulloblastomaa3388.5Relapse Burkitt's lymphomaa805.7JMMLa35212.8Metastaticmedulloblastomaa, b18812.0Myelodysplastic syndrome + AMLa1823.6Anaplastic large cell lymphoma1469.3Myelodysplastic syndrome770.7HLH21610.0Embryonal sarcoma of liver6502.8Stage IV neuroblastomaa37315.8Relapsed T cell ALLa4711.6AMLa6810.0Medulloblastoma3800.6HLH3682.7Stage M neuroblastomaa884.2Aplastic anemia618.8Idiopathic aplastic anemia552.6Rhabdomyosarcoma of ear2833.0Myelodysplastic syndromea1160.6HLHa2511.0Hurler syndrome3674.4Stage IV neuroblastomaa2357.4Neuroblastoma25710.1Pineal NGGCT2040.8Ewing's sarcoma13712.4Medulloblastoma327Mean ± SD6.9 ± 4.4Mean ± SD229 ± 150.3aPrior chemotherapy.bPrior radiation therapy.