Testosterone prior to hypospadias repair: Postoperative complication rates and long-term cosmetic results, penile length and body height

This study suggested that the long-term results of patients receiving pre-operative testosterone treatment, who often had more challenging hypospadias, were similar to those who did not. However, a randomised controlled study is needed to confirm these results.Summary Table. Outcomes of multivariate regression analysis: impact of hypospadias severity versus pre-operative testosterone use on adult penile length and height, and cosmetic outcome measured by the Pediatric Penile Perception Score (PPPS).Outcome variableUnivariate analysisMultiple linear regressionPredictor variableRhoPβPCI (95%)Penile length (cm)Hypospadias type−0.48<0.01−2.9*<0.01−4.4 to 1.4**Testosterone use−0.110.400.60.32−0.6 to 1.8Adult height (cm)Hypospadias type−0.130.33NSTestosterone use−0.340.80NSOutcome variableUnivariate analysisLogistic regressionPredictor variableRhoPORPCI (95%)General aspect (PPPS)Dissatisfied vs. satisfiedHypospadias type0.110.41NSTestosterone−0.070.60NSHypospadias type ranged from distal (1), midshaft (2) and proximal (3) hypospadias.Testosterone use: no testosterone (0) versus pre-operative testosterone treatment (1).Pediatric Penile Perception Score (PPPS): (very) dissatisfied outcome (0) versus (very) satisfied outcome (1).Rho: Spearman's rank correlation.OR: odds ratio.*outcome for proximal hypospadias (1) compared to the remaining hypospadias subtypes (0).**R2, 019.