Frequency of gonadal tumours in complete androgen insensitivity syndrome (CAIS): A retrospective case-series analysis

The results support the current recommendation that gonads in CAIS can be retained until early adulthood. The small number of individuals with gonadectomy after age 20 years do not allow firm conclusion regarding later adulthood. Therefore, it is recommended that the option of gonadectomy be discussed in adulthood. Some form of regular surveillance of the gonads is then recommended, although none of the available options are ideal.Summary table. Abnormal histology.Benign tumourn = 6 Sertoli cell adenoma (SCA)n = 8 testicular hamartoma (TH)n = 2 mixed SCA + THGerm cell neoplasia in situ (GCNIS) (age at gonadectomy)n = 6 (2 years 9 months, 16 years, 17 years,*17 years, 20 years,*53 years)*Associated with benign changesMalignant tumour (age at gonadectomy)n = 1 malignant sex cord stromal tumour (68 years)n = 1 seminoma (30 years)