Obese Children Require Lower Doses of Pantoprazole Than Nonobese Peers to Achieve Equal Systemic Drug Exposures

Article ID	Journal	Published Year	Pages	File Type
8812566	The Journal of Pediatrics	2018	8 Pages	PDF

Abstract

ClinicalTrials.gov: NCT02186652

Keywords

EMS AUClast CYP2C19 AUCinf TBW PPIs GERD time to Cmax tmax LBW Lean body weight IMS FDA CyP Cmax AUC CL/F t1/2 gastroesophageal reflux disease Food and Drug Administration cytochrome body mass index BMI adverse event Peak plasma concentration Pharmacokinetics poor metabolizer Obesity area under the concentration time curve Proton pump inhibitors Half-life Total body weight Pediatrics

Related Topics

Health Sciences Medicine and Dentistry Perinatology, Pediatrics and Child Health

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Obese Children Require Lower Doses of Pantoprazole Than Nonobese Peers to Achieve Equal Systemic Drug Exposures

Authors

Valentina MD, P. Brian MD, MHS, MPH, Jeffrey T. MD, MA, MHS, Laura P. MD, David N. MD, PhD, FAAP, Huali PhD, Chad E. MBA, Jian PhD, Gregory L. PharmD, PhD,