Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8814166 | Biological Psychiatry | 2018 | 294 Pages |
Abstract
Overall, this study provides biological evidence that the SZ-risk gene DGCR2 regulates critical steps of early corticogenesis possibly through a Reelin-dependent mechanism. Additionally, we found that the SZ-risk mutation in DGCR2 has a pathogenic impact on cortical formation by reducing protein expression level, suggesting a functional role for DGCR2 haploinsufficiency in the 22q11.2 deletion syndrome.
Related Topics
Life Sciences
Neuroscience
Biological Psychiatry
Authors
Aude Molinard-Chenu, Alexandre Dayer,