Article ID Journal Published Year Pages File Type
8814166 Biological Psychiatry 2018 294 Pages PDF
Abstract
Overall, this study provides biological evidence that the SZ-risk gene DGCR2 regulates critical steps of early corticogenesis possibly through a Reelin-dependent mechanism. Additionally, we found that the SZ-risk mutation in DGCR2 has a pathogenic impact on cortical formation by reducing protein expression level, suggesting a functional role for DGCR2 haploinsufficiency in the 22q11.2 deletion syndrome.
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Life Sciences Neuroscience Biological Psychiatry
Authors
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