Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
8814188 | Biological Psychiatry | 2018 | 56 Pages |
Abstract
Using latent factor models, we identified developmental changes in the genetic architecture of social communication difficulties that enhance the understanding of autism spectrum disorder- and schizophrenia-related dimensions. More generally, genetic-relationship-matrix structural equation models present a framework for modeling shared genetic etiologies between phenotypes and can provide prior information with respect to patterns and continuity of trait-disorder overlap.
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Authors
Beate St Pourcain, Lindon J. Eaves, Susan M. Ring, Simon E. Fisher, Sarah Medland, David M. Evans, George Davey Smith,