Article ID Journal Published Year Pages File Type
8814501 Biological Psychiatry: Cognitive Neuroscience and Neuroimaging 2018 9 Pages PDF
Abstract
In adults with SZ, the relationship between length of exposure to oral second-generation antipsychotics and ICM was positive during the first year of treatment but was negative after this initial period, consistent with suboptimal later adherence after initial adherence. This ICM trajectory resembles clinically observed antipsychotic response trajectory with high rates of remission in the first year followed by progressively lower response rates. The results support postmortem evidence that SZ pathophysiology involves ICM deficits and suggest that correcting these deficits may be an important mechanism of action for antipsychotics.
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Life Sciences Neuroscience Biological Psychiatry
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